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When statin takers eat large amounts of grapefruit the level.
What happens if you eat grapefruit with atorvastatin. It has a big impact on atorvastatin Lipitor lovastatin Mevacor and simvastatin Zocor but little or no effect on fluvastatin Lescol pitavastatin Livalo pravastatin Pravachol and rosuvastatin Crestor. It might seem like a strange association but certain statins like atorvastatin Lipitor and simvastatin Zocor can interact with grapefruit and grapefruit juice increasing your risk for harmful side effects. This can increase the risk of muscle breakdown liver damage and even kidney failure.
Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely. Some drugs like certain statins used to lower cholesterol are broken. But grapefruits reputation for interfering with some medications is well-deserved.
Rhabdomyolysismuscle breakdown Liver damage Increased blood sugar Problems with digestion Joint or muscle pain Neurological effects. When the action of these enzymes is blocked as by grapefruit juice more of the drugs get into the body and the blood levels of these medications increase. Those adverse effects may include.
Click to see full answer. Atorvastatin interacts with grapefruit juice if you drink large quantities more than 12 litres daily but an occasional glass is thought to be safe. This means that even if you consume grapefruit juice early in the day and then take the medication at bedtime you are still at risk for experiencing side effects.
Grapefruit and grapefruit juice can inhibit CYP3A metabolizing enzymes which are responsible for Lipitor atorvastatin metabolism. Simvastatin and lovastatin are increased by 260 percent. Grapefruit juice can cause problems with these enzymes and transporters causing too much or too little drug in the body.
The effect on drug metabolism can last for several days so. You should avoid large quantities of grapefruit or grapefruit juice which can increase the risk of serious side effects. Grapefruit juice can cause that statin to stay in your body much longer and the drug can build up.
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